Sometimes drugs are dissolved in water and then inserted into the vagina. There is very little evidence that drugs are effective when inserted into the vagina.
You may want to consider doing these things if you do decide to insert drugs into your vagina:
Use a tester amount first.
The vagina is a very sensitive area and even a small amount of a drug can cause discomfort, itching and burning. If you are inserting a drug into the vagina, use a tester amount first to ensure it doesn’t sting or burn you.
Dissolve your drug in water before inserting.
Avoid inserting pills, crystals, or powders directly into your vagina. There is not enough fluid in your vagina for solids to dissolve. Mixing your drugs with water before you insert them reduces the potential for damage to the delicate membrane inside the vagina.
Insert with care.
Gently insert the diluted drug into your vagina with a clean tool, ideally a sterile syringe (without the needle) and use lube. Cover the syringe in lube to reduce friction and insert into the vagina with clean hands. Do not share syringes with others as this can pass on blood borne viruses and bacteria.
Rinse the area out with water afterwards.
Use a douche or a clean vessel such as an unused drink bottle or sterile syringe (without the needle) to insert fresh water into your vagina. This will help to clean the area and get rid of any residual drugs that can cause discomfort, burning or damage.
Think about safer sex.
Some drugs can make the vagina and surrounding area very numb. You may be less likely to notice discomfort, soreness, or damage during penetrative sexual acts. Consider waiting until the effects and numbness have worn off.
It is also important to use protection when having vaginal intercourse, especially after inserting drugs. This is because drugs can cause tears or burns to the area, making you more susceptible to the transmission of sexually transmitted infections and bacteria.
Take long breaks between use, and get help if discomfort persists.
Inserting drugs into your vagina can cause damage, burning, itching and changes to your PH levels that can persist for some time after using. Consider taking long breaks to allow the delicate membranes to recover. If irritation, swelling or any other symptoms persist, see a medical professional.